Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30546510 | 0.84 | HDAC8 (0.36) | NPC1PDE10ADGAT1 | |
| SCHEMBL30546525 | 0.81 | NPC1 (0.35) | NPC1 | |
| SCHEMBL4718492 | 0.79 | ALDH1A1 (0.39) | NPC1KDM4EMEN1ALDH1A1POLB | |
| SCHEMBL29810321 | 0.79 | NPC1 (0.35) | NPC1 | |
| SCHEMBL27191935 | 0.78 | PARP1 (0.35) | NPC1PDE10ADGAT1 | |
| SCHEMBL10452108 | 0.77 | NPC1 (0.36) | NPC1ALDH1A1PDE10ADGAT1 | |
| SCHEMBL25239263 | 0.75 | DGAT1 (0.33) | NPC1MAPTDGAT1 | |
| SCHEMBL25323155 | 0.75 | DGAT1 (0.37) | NPC1PDE10ADGAT1 | |
| SCHEMBL6118775 | 0.75 | ALDH1A1 (0.41) | NPC1KDM4EMEN1TDP2NSD2 | |
| SCHEMBL3348756 | 0.74 | MPO (0.46) | NPC1KDM4EMEN1TDP2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007085540-A1 | 1H-INDAZ0L-4-YL-2 , 4-PYRIMIDINEDIAMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-08-02 | — | — | WO | disclosed |
| WO-2007028445-A1 | 6-INDOLYL-4-YL-AMINO-5-HALOGENO-2-PYRIMIDINYL-AMINO DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007009681-A1 | 1 , 1-DIOXID0-2 , 3-DIHYDRO-l , 2-BENZISOTHIAZ0L-6-YL-1H-INDAZOL-4-YL-2 , 4-PYRIMIDINEDI AMINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-01-25 | — | — | WO | disclosed |