Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508979 | 0.88 | GRM5 (0.58) | GRM5ACHEPRMT5WDR77ITGB3 | |
| SCHEMBL1002943 | 0.82 | ADAM17 (0.57) | GRM5ACHEMEN1KMT2AADAM17 | |
| SCHEMBL2023150 | 0.76 | GRM5 (0.50) | GRM5ACHEMEN1KMT2AADAM17 | |
| SCHEMBL12581806 | 0.75 | MEN1 (0.50) | GRM5ACHEMEN1KMT2AHDAC4 | |
| SCHEMBL31409566 | 0.75 | HDAC1 (0.49) | GRM5ACHEMEN1KMT2AADAM17 | |
| SCHEMBL5282876 | 0.75 | HDAC1 (0.49) | GRM5ACHEMEN1KMT2AADAM17 | |
| SCHEMBL1500111 | 0.75 | HDAC1 (0.49) | GRM5ACHEMEN1KMT2AHDAC4 | |
| SCHEMBL3225584 | 0.75 | GRM5 (0.49) | GRM5ACHEMEN1KMT2AHDAC4 | |
| SCHEMBL19967154 | 0.74 | DHPS (0.52) | GRM5MEN1KMT2AHDAC4HDAC1 | |
| SCHEMBL12581703 | 0.74 | GRM5 (0.46) | GRM5ACHEMEN1KMT2AHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007000337-A1 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | disclosed |