Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | FKBP1A | P62942 | 11/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15156267 | 0.86 | MEN1 (0.60) | ALDH1A1FKBP1APOLBKDM4EUSP2 | |
| SCHEMBL528962 | 0.85 | GAA (0.70) | ALDH1A1FKBP1APOLBKDM4ERECQL | |
| SCHEMBL15156731 | 0.85 | TPSAB1 (0.58) | ALDH1A1FKBP1AKDM4EUSP2HPGD | |
| SCHEMBL5692472 | 0.84 | ALDH1A1 (1.00) | ALDH1A1FKBP1ASMN1; SMN2MAPTPOLB | |
| SCHEMBL3630046 | 0.83 | ALDH1A1 (0.60) | ALDH1A1FKBP1ASMN1; SMN2MAPTPOLB | |
| SCHEMBL3096037 | 0.83 | FKBP1A (0.74) | ALDH1A1FKBP1ASMN1; SMN2MAPTPOLB | |
| SCHEMBL13606473 | 0.82 | FKBP1A (0.72) | ALDH1A1FKBP1ASMN1; SMN2MAPTPOLB | |
| SCHEMBL12409096 | 0.82 | KDM4E (0.78) | ALDH1A1FKBP1ASMN1; SMN2MAPTPOLB | |
| SCHEMBL2229109 | 0.82 | FKBP1A (0.72) | ALDH1A1FKBP1ASMN1; SMN2MAPTPOLB | |
| SCHEMBL8320871 | 0.81 | ALDH1A1 (0.79) | ALDH1A1FKBP1ASMN1; SMN2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597953-A1 | METHOD FOR TREATING OPHTHALMIC DISEASES USING KINASE INHIBITOR COMPOUNDS IN PRODRUG FORMS | Inspire Pharmaceuticals, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012015760-A1 | METHOD FOR TREATING OPHTHALMIC DISEASES USING KINASE INHIBITOR COMPOUNDS IN PRODRUG FORMS | INSPIRE PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | disclosed |
| WO-1996028448-A1 | 6-ARYL PYRAZOLO[3,4-d]PYRIMIDIN-4-ONES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-09-19 | — | — | WO | disclosed |