SCHEMBL5284909

SCHEMBL5284909

CC(C)=NN=c1sc2cc(OCC(=O)NN)ccc2n1C

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.47
TP53 P04637 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
KDM4E B2RXH2 2/20 0.47
POLB P06746 1/20 0.47
HPGD P15428 1/20 0.47
HSD17B10 Q99714 1/20 0.47
KCNQ3 O43525 11/20 0.44
KCNQ2 O43526 11/20 0.44
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41
ALDH1A1 P00352 1/20 0.39
THRB P10828 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5284896 1.00 MAPT (0.47) MAPTTP53SMN1; SMN2KDM4EPOLB
SCHEMBL4616442 0.87 MAPT (0.50) MAPTTP53SMN1; SMN2KDM4EPOLB
SCHEMBL4623298 0.87 MAPT (0.50) MAPTTP53SMN1; SMN2KDM4EPOLB
SCHEMBL5278485 0.82 MAPT (0.60) MAPTTP53SMN1; SMN2KDM4EPOLB
SCHEMBL5277827 0.78 SMN1; SMN2 (0.45) MAPTTP53SMN1; SMN2KDM4EPOLB
SCHEMBL5380440 0.77 OGG1 (0.42) MAPTSMN1; SMN2KDM4EHPGDKCNQ3
SCHEMBL5380433 0.77 OGG1 (0.42) MAPTSMN1; SMN2KDM4EHPGDKCNQ3
SCHEMBL5278873 0.73 TP53 (0.49) MAPTTP53SMN1; SMN2KDM4EPOLB
SCHEMBL5278876 0.73 TP53 (0.49) MAPTTP53SMN1; SMN2KDM4EPOLB
SCHEMBL5283631 0.72 MAPT (0.48) MAPTTP53SMN1; SMN2KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599178-B1 MEANS AND METHOD FOR DYEING KERATIN FIBRES WELLA AG (DE) 2007-12-19 EP claimed
US-7294151-B2 Means and method for dyeing keratin fibres WELLA AG (DE) 2007-11-13 US claimed
US-20060070190-A1 Means and method for dyeing keratin fibres KOYO SEIKO CO., LTD. (JP) 2006-04-06 US claimed
US-7294151-B2 Means and method for dyeing keratin fibres WELLA AG (DE) 2007-11-13 US disclosed
US-20060070190-A1 Means and method for dyeing keratin fibres KOYO SEIKO CO., LTD. (JP) 2006-04-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060070190-A1 Means and method for dyeing keratin fibres KRT18, KLK5, KIT MAPT 1807/4885TP53 2281/4885SMN1; SMN2 3523/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.