Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210830 | 0.93 | MAPT (0.43) | MAPTTP53POLB | |
| SCHEMBL5206559 | 0.92 | MAPT (0.46) | PPARAPPARGMAPTTP53ALDH1A1 | |
| SCHEMBL2521112 | 0.90 | LMNA (0.44) | PPARAPPARGMAPTSMN1; SMN2TP53 | |
| SCHEMBL2521111 | 0.90 | LMNA (0.44) | PPARAPPARGMAPTSMN1; SMN2TP53 | |
| SCHEMBL5213499 | 0.88 | MAPT (0.42) | PPARAPPARGMAPTTP53ALDH1A1 | |
| SCHEMBL5205909 | 0.86 | PPARA (0.49) | PPARAPPARGMAPTTP53POLB | |
| SCHEMBL5210969 | 0.85 | HRH3 (0.44) | PPARAPPARG | |
| SCHEMBL5211183 | 0.84 | ALDH1A1 (0.38) | MAPTSMN1; SMN2TP53ALDH1A1POLB | |
| SCHEMBL2523386 | 0.83 | MAPT (0.46) | MAPTTP53ALDH1A1POLBHPGD | |
| SCHEMBL2523387 | 0.83 | MAPT (0.46) | MAPTTP53ALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448523-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | NOVARTIS AG (CH) | 2007-08-22 | — | — | EP | claimed |