Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | DHPS | P49366 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5281504 | 0.89 | MAPT (0.46) | LMNAMAPTHTTALDH1A1NPSR1 | |
| SCHEMBL5289070 | 0.88 | LMNA (0.49) | LMNAMAPTHTTALDH1A1NPSR1 | |
| SCHEMBL5283873 | 0.87 | MAPT (0.47) | LMNAMAPTHTTALDH1A1NPSR1 | |
| SCHEMBL5110787 | 0.86 | CYP1A2 (0.57) | LMNAMAPTHTTALDH1A1NPSR1 | |
| SCHEMBL5296815 | 0.86 | MAPT (0.48) | LMNAMAPTHTTALDH1A1NPSR1 | |
| SCHEMBL5289551 | 0.86 | MAPT (0.48) | LMNAMAPTHTTALDH1A1NPSR1 | |
| SCHEMBL5280720 | 0.85 | PDGFRB (0.42) | HTTALDH1A1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL5281477 | 0.81 | PDGFRB (0.43) | HTTALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL5114057 | 0.81 | TDP1 (0.53) | LMNAALDH1A1L3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL5280054 | 0.81 | MAPT (0.41) | MAPTHTTALDH1A1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866289-A1 | PYRIMIDINE CARBOXYLIC ACID DERIVATIVES AND USE THEREOF | Bayer HealthCare AG (DE) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006097220-A1 | PYRIMIDINE CARBOXYLIC ACID DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-09-21 | — | — | WO | disclosed |