SCHEMBL5287035

SCHEMBL5287035

CC(NC(=N)N)C(N)C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.46
SLC1A2 P43004 2/20 0.35
SLC1A3 P43003 1/20 0.35
SLC1A1 P43005 1/20 0.35
FOLH1 Q04609 2/20 0.32
NAALAD2 Q9Y3Q0 2/20 0.32
ENPEP Q07075 2/20 0.32
DPP4 P27487 1/20 0.31
FAP Q12884 1/20 0.31
DPP8 Q6V1X1 1/20 0.31
DPP9 Q86TI2 1/20 0.31
DPP7 Q9UHL4 1/20 0.31
TP53 P04637 1/20 0.31
NOS3 P29474 1/20 0.31
NOS1 P29475 1/20 0.31
NOS2 P35228 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23586947 1.00 SLC7A5 (0.46) SLC7A5SLC1A2SLC1A3SLC1A1FOLH1
SCHEMBL17234150 1.00 SLC7A5 (0.46) SLC7A5SLC1A2SLC1A3SLC1A1FOLH1
SCHEMBL17234225 1.00 SLC7A5 (0.46) SLC7A5SLC1A2SLC1A3SLC1A1FOLH1
SCHEMBL17234221 1.00 SLC7A5 (0.46) SLC7A5SLC1A2SLC1A3SLC1A1FOLH1
SCHEMBL17234149 1.00 SLC7A5 (0.46) SLC7A5SLC1A2SLC1A3SLC1A1FOLH1
SCHEMBL10056006 0.82 SLC7A5 (0.50) SLC7A5SLC1A2SLC1A3SLC1A1DPP4
SCHEMBL17234433 0.80 FOLH1 (0.33) SLC7A5FOLH1NAALAD2TP53NOS3
SCHEMBL17234442 0.80 FOLH1 (0.33) SLC7A5FOLH1NAALAD2TP53NOS3
SCHEMBL24241819 0.80 FOLH1 (0.33) SLC7A5FOLH1NAALAD2TP53NOS3
SCHEMBL17030071 0.80 FOLH1 (0.33) SLC7A5FOLH1NAALAD2TP53NOS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3224359-B1 ARGININE IMPROVES POLYMERASE STORAGE STABILITY BIO RAD LABORATORIES INC (US) 2023-10-25 EP claimed
CN-114214061-B Polyethylene glycol modified zwitterionic fluorescent probe, preparation and application thereof 北京大学 2022-05-17 CN claimed
CN-114214061-A Polyethylene glycol modified zwitterionic fluorescent probe, preparation and application thereof 北京大学 2022-03-22 CN claimed
US-5658885-A OLIGOPEPTIDES; ANTICOAGULANTS; ENZYME INHIBITORS; THROMBIN THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1997-08-19 US claimed
EP-3224359-B1 ARGININE IMPROVES POLYMERASE STORAGE STABILITY BIO RAD LABORATORIES INC (US) 2023-10-25 EP disclosed
CN-115379831-A Nanoparticles encapsulating small molecules 苏黎世联邦理工学院 2022-11-22 CN disclosed
CN-114214061-B Polyethylene glycol modified zwitterionic fluorescent probe, preparation and application thereof 北京大学 2022-05-17 CN disclosed
CN-114214061-A Polyethylene glycol modified zwitterionic fluorescent probe, preparation and application thereof 北京大学 2022-03-22 CN disclosed
EP-3950673-A1 INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF Inspirna, Inc. (US) 2022-02-09 EP disclosed
EP-3137447-B1 INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF RGENIX INC (US) 2021-06-30 EP disclosed
US-10053676-B2 Arginine improves polymerase storage stability BIO-RAD LABORATORIES, INC. (US) 2018-08-21 US disclosed
US-20160145587-A1 ARGININE IMPROVES POLYMERASE STORAGE STABILITY BIO-RAD LABORATORIES, INC. 2016-05-26 US disclosed
US-20020065248-A1 Inhibitors of hepatitis C virus NS3 protease BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-05-30 US disclosed
EP-1196436-A2 PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE Bristol-Myers Squibb Pharma Company (US) 2002-04-17 EP disclosed
WO-2001064678-A2 INHIBITORS OF HEPATITIS C VIRUS NS3 PROTEASE BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2001-09-07 WO disclosed
WO-2001040262-A1 ALPHA-KETOAMIDE INHIBITORS OF HEPATITIS C VIRUS NS3 PROTEASE BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2001-06-07 WO disclosed
WO-2001002424-A2 PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE DU PONT PHARMACEUTICALS COMPANY (US) 2001-01-11 WO disclosed
US-5658885-A OLIGOPEPTIDES; ANTICOAGULANTS; ENZYME INHIBITORS; THROMBIN THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1997-08-19 US disclosed
EP-0787010-A1 AMIDINO AND GUANIDINO SUBSTITUTED INHIBITORS OF TRYPSIN-LIKE ENZYMES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1997-08-06 EP disclosed
WO-1996012499-A1 AMIDINO AND GUANIDINO SUBSTITUTED INHIBITORS OF TRYPSIN-LIKE ENZYMES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-05-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020065248-A1 Inhibitors of hepatitis C virus NS3 protease TMPRSS15, CTRC, CPN1 SLC7A5 860/4885SLC1A2 3427/4885SLC1A3 2604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.