Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 4/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KLK1 | P06870 | 2/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5302849 | 0.93 | KLKB1 (0.45) | ADRA2BKLKB1SMN1; SMN2KLK1KLK5 | |
| SCHEMBL2297333 | 0.90 | ADRA2B (0.49) | ADRA2BSMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL2297485 | 0.88 | KMT2A (0.47) | SMN1; SMN2KLK1KLK5KDRNPC1 | |
| SCHEMBL2295353 | 0.86 | RAB9A (0.45) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| SCHEMBL2295738 | 0.86 | MEN1 (0.45) | ADRA2BSMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL2296926 | 0.85 | KMT2A (0.49) | SMN1; SMN2MAPTNPC1RAB9AKCNK3 | |
| SCHEMBL2295816 | 0.84 | RAB9A (0.45) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 | |
| SCHEMBL5292979 | 0.84 | RAB9A (0.43) | SMN1; SMN2MAPTNPC1RAB9AHSD17B10 | |
| SCHEMBL2298509 | 0.84 | NR1H4 (0.47) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL2295817 | 0.83 | FADS1 (0.46) | SMN1; SMN2NPC1RAB9AHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |