Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5324144 | 0.77 | HRH3 (0.38) | HRH3GLATP53KDM4EALDH1A1 | |
| SCHEMBL4415421 | 0.76 | GAA (0.56) | PDCD1CD274PPARACA1CA2 | |
| SCHEMBL21066539 | 0.75 | PDCD1 (0.49) | PDCD1CD274CA1CA2L3MBTL1 | |
| SCHEMBL4709745 | 0.75 | PDCD1 (0.52) | PDCD1CD274TP53MAPTSMN1; SMN2 | |
| SCHEMBL29904798 | 0.75 | L3MBTL1 (0.48) | KDM4EMAPTCA1CA2L3MBTL1 | |
| SCHEMBL6076877 | 0.74 | HPGD (0.49) | PDCD1CD274KDM4EALDH1A1CA1 | |
| SCHEMBL12310009 | 0.74 | CA1 (0.47) | PDCD1CD274CA1CA2L3MBTL1 | |
| SCHEMBL1724201 | 0.74 | GAA (0.60) | PDCD1CD274KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL22452272 | 0.74 | FPR3 (0.47) | PDCD1CD274SMN1; SMN2CA1CA2 | |
| SCHEMBL5479565 | 0.74 | CYP17A1 (0.50) | PDCD1CD274ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008144-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |