Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.50 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757744 | 0.89 | MGAM (0.54) | MGAMSRPK1RPS6KB2EGLN1PDGFRB | |
| SCHEMBL4398475 | 0.80 | MGAM (0.68) | MGAMEGLN1PDGFRBPDGFRAKDM4E | |
| SCHEMBL529465 | 0.77 | MAP4K4 (0.63) | MGAMPDGFRBPDGFRA | |
| SCHEMBL10080493 | 0.76 | SRPK1 (0.57) | SRPK1RPS6KB2EGLN1KDM4EMAPT | |
| SCHEMBL10465639 | 0.76 | MGAM (0.70) | MGAMPDGFRBPDGFRAKDM4EMAPT | |
| SCHEMBL529524 | 0.76 | MGAM (0.57) | MGAMEGLN1PDGFRBPDGFRAMEN1 | |
| SCHEMBL12504970 | 0.75 | MGAM (0.56) | MGAMEGLN1CHEK1CYP1A2CYP2C19 | |
| SCHEMBL15774917 | 0.74 | KDM4E (0.64) | MGAMKDM4EMAPTSMN1; SMN2HPGD | |
| SCHEMBL569420 | 0.74 | CYP2E1 (0.50) | SRPK1RPS6KB2EGLN1KDM4ECHEK1 | |
| SCHEMBL6237548 | 0.73 | KDM4E (0.60) | SRPK1RPS6KB2PDGFRBKDM4ERXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |