Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
| ▸ | CDK8 | P49336 | 1/20 | 0.63 |
| ▸ | CLK2 | P49760 | 1/20 | 0.63 |
| ▸ | CDK7 | P50613 | 1/20 | 0.63 |
| ▸ | CDK9 | P50750 | 1/20 | 0.63 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.63 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.63 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.63 |
| ▸ | MGAM | O43451 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.47 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.47 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398475 | 0.88 | MGAM (0.68) | MAP4K4CDK8CLK2CDK7CDK9 | |
| SCHEMBL529524 | 0.86 | MGAM (0.57) | MAP4K4CDK8CLK2CDK7CDK9 | |
| SCHEMBL1352698 | 0.84 | MAP4K4 (0.58) | MAP4K4CDK8CLK2CDK7CDK9 | |
| SCHEMBL10465639 | 0.80 | MGAM (0.70) | MGAMPDGFRBPDGFRANAPRT | |
| SCHEMBL12504970 | 0.79 | MGAM (0.56) | MAP4K4CDK8CLK2CDK7CDK9 | |
| SCHEMBL3787407 | 0.79 | MGAM (0.64) | MGAMCSNK2A2CSNK2BNAPRT | |
| SCHEMBL12132266 | 0.78 | MGAM (0.51) | MAP4K4CDK8CLK2CDK7CDK9 | |
| SCHEMBL528875 | 0.77 | MGAM (0.54) | MGAMPDGFRBPDGFRA | |
| SCHEMBL28055368 | 0.76 | MGAM (0.60) | MAP4K4MGAMPDGFRBPDGFRAMKNK1 | |
| SCHEMBL61876 | 0.76 | MGAM (0.64) | MAP4K4CDK8CLK2CDK7CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |