Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.53 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528875 | 0.89 | MGAM (0.54) | MGAMSRPK1RPS6KB2EGLN1HDAC2 | |
| SCHEMBL5757063 | 0.82 | MAOB (0.53) | HDAC2PDGFRBPDGFRAKDM4EMAPT | |
| SCHEMBL28055368 | 0.78 | MGAM (0.60) | MGAMPDGFRBPDGFRAKDM4EHPGDS | |
| SCHEMBL5762283 | 0.77 | PDGFRB (0.45) | RPS6KB2HDAC2PDGFRBPDGFRACHEK1 | |
| SCHEMBL10080493 | 0.76 | SRPK1 (0.57) | SRPK1RPS6KB2EGLN1HDAC2KDM4E | |
| SCHEMBL69368 | 0.74 | MGAM (0.68) | MGAMPDGFRBPDGFRAKDM4EMAPT | |
| SCHEMBL27402367 | 0.74 | PDGFRB (0.58) | RPS6KB2PDGFRBPDGFRAKDM4EMAPT | |
| SCHEMBL5762231 | 0.74 | PDGFRB (0.45) | RPS6KB2HDAC2PDGFRBPDGFRAKDM4E | |
| SCHEMBL569420 | 0.74 | CYP2E1 (0.50) | SRPK1RPS6KB2EGLN1HDAC2CHEK1 | |
| SCHEMBL420705 | 0.72 | KDM4E (0.55) | SRPK1RPS6KB2EGLN1HDAC2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1270571-B1 | Heterocyclic compounds, their production and use | TAKEDA PHARMACEUTICAL (JP) | 2006-09-06 | — | — | EP | disclosed |
| EP-1270571-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |
| US-6211215-B1 | AROMATIC HETEROCYCLIC COMPOUND WITH AZOLE COMPOUND | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0912562-A1 | HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998003505-A2 | HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-29 | — | — | WO | disclosed |