Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | GAA | P10253 | 4/20 | 0.60 |
| ▸ | CASP1 | P29466 | 2/20 | 0.60 |
| ▸ | CASP7 | P55210 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.60 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.53 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PRNP | P04156 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8504154 | 0.83 | NPC1 (0.65) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL6238757 | 0.80 | RPS6KB2 (0.79) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL23416316 | 0.80 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL4124485 | 0.79 | RAB9A (0.62) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL28450107 | 0.77 | NPC1 (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL31393433 | 0.76 | NPC1 (1.00) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL708998 | 0.76 | NPC1 (1.00) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL3200853 | 0.75 | HPGDS (0.67) | KDM4ESRPK1RPS6KB2KMT2AHPGDS | |
| SCHEMBL6235717 | 0.75 | RPS6KB2 (0.66) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL19066630 | 0.75 | NPC1 (0.96) | KDM4EALDH1A1HPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |