Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL529735 | 0.86 | HTT (0.42) | HTTLMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL529732 | 0.84 | HTT (0.44) | HTTLMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL528765 | 0.83 | RXFP1 (0.42) | HTTLMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL528913 | 0.82 | NPC1 (0.45) | HTTLMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL27448960 | 0.75 | HTT (0.38) | HTTLMNAMAPTNPSR1RXFP1 | |
| SCHEMBL529947 | 0.74 | HTT (0.39) | HTTLMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL15191355 | 0.73 | HTT (0.50) | HTTLMNASMN1; SMN2NPSR1RXFP1 | |
| SCHEMBL15191291 | 0.73 | HTT (0.47) | HTTLMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL14899564 | 0.72 | TNF (0.45) | HTTLMNASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL16589027 | 0.72 | ALK (0.44) | HTTLMNASMN1; SMN2MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |