Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 4/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2294482 | 0.93 | NAMPT (0.48) | ITGB1ITGA4NPC1RAB9AKDM4E | |
| SCHEMBL5305129 | 0.93 | NPC1 (0.49) | ITGB1ITGA4NPC1RAB9AKDM4E | |
| SCHEMBL2298594 | 0.91 | KMT2A (0.46) | ITGB1ITGA4NPC1RAB9AKDM4E | |
| SCHEMBL2295665 | 0.91 | PSEN1 (0.45) | ITGB1ITGA4NPC1RAB9AKDM4E | |
| SCHEMBL2294562 | 0.91 | MAPT (0.44) | ITGB1ITGA4NPC1RAB9AKDM4E | |
| SCHEMBL2292763 | 0.90 | MAPT (0.50) | RAB9AKDM4EMAPTNLRP3SMN1; SMN2 | |
| SCHEMBL5291502 | 0.88 | BCHE (0.46) | ITGB1ITGA4NPC1RAB9AKDM4E | |
| SCHEMBL2294711 | 0.87 | ALDH1A1 (0.47) | KDM4EMAPTSMN1; SMN2NAMPTFNTA | |
| SCHEMBL2299138 | 0.87 | NOTUM (0.46) | ITGB1ITGA4NPC1RAB9AMAPT | |
| SCHEMBL2292564 | 0.87 | NPC1 (0.51) | NPC1RAB9AKDM4ETP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |