Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2291392 | 0.93 | KMT2A (0.51) | NPC1RAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL5289381 | 0.93 | ITGB1 (0.44) | NPC1RAB9ASMN1; SMN2KDM4EITGB1 | |
| SCHEMBL2297135 | 0.91 | KMT2A (0.46) | NPC1RAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL2299666 | 0.91 | KMT2A (0.48) | NPC1RAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL2299814 | 0.91 | LMNA (0.45) | NPC1RAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL2297605 | 0.90 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL5295744 | 0.88 | BCHE (0.46) | NPC1RAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL2299928 | 0.87 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL2295280 | 0.87 | KMT2A (0.50) | NPC1RAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL2294968 | 0.87 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |