Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.50 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.43 |
| ▸ | CHRNG | P07510 | 1/20 | 0.43 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.43 |
| ▸ | CHRND | Q07001 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3329262 | 0.83 | LTA4H (0.52) | LTA4HPOLBCHRNB4CHRNA3CHRNB2 | |
| SCHEMBL1116568 | 0.83 | LTA4H (0.52) | LTA4HPOLBCHRNB4CHRNA3CHRNB2 | |
| SCHEMBL1116569 | 0.83 | LTA4H (0.52) | LTA4HPOLBCHRNB4CHRNA3CHRNB2 | |
| SCHEMBL11969843 | 0.82 | LTA4H (0.42) | LTA4HPOLBKMT2AMETAP2CYP1A2 | |
| SCHEMBL10891765 | 0.80 | LTA4H (0.49) | LTA4HCYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL4374404 | 0.78 | POLB (0.57) | LTA4HPOLBKMT2ACYP1A2CYP2D6 | |
| SCHEMBL4381640 | 0.77 | POLB (0.56) | LTA4HPOLBKMT2ACYP1A2CYP2D6 | |
| SCHEMBL4654443 | 0.74 | LTA4H (0.51) | LTA4HPOLBCHRNB4CHRNA3CHRNB2 | |
| SCHEMBL1751545 | 0.74 | LTA4H (0.51) | LTA4HPOLBCHRNB4CHRNA3CHRNB2 | |
| SCHEMBL3289066 | 0.74 | ACHE (0.52) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863805-A1 | PYRIMIDINE COMPOUNDS HAVING TIE2 (TEK) INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006082373-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2006-08-10 | — | — | WO | disclosed |