Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6037950 | 0.84 | TP53 (0.38) | TP53LMNAMAPTGAAHTT | |
| SCHEMBL5280650 | 0.83 | RAB9A (0.45) | TP53LMNAMAPTRAB9AHDAC1 | |
| SCHEMBL5286061 | 0.82 | ALDH1A1 (0.55) | TP53LMNAMAPTGAAPOLB | |
| SCHEMBL5282822 | 0.82 | HDAC1 (0.46) | TP53LMNAMAPTRAB9AHDAC1 | |
| SCHEMBL6038118 | 0.82 | HDAC1 (0.39) | TP53LMNAMEN1KMT2ARAB9A | |
| SCHEMBL5290863 | 0.81 | HDAC1 (0.44) | TP53LMNAMAPTGAAHTT | |
| SCHEMBL5282375 | 0.81 | AOC3 (0.47) | TP53LMNAKMT2ARAB9A | |
| SCHEMBL5282979 | 0.81 | TP53 (0.43) | TP53LMNAMAPTRAB9AGAA | |
| SCHEMBL5275941 | 0.80 | TP53 (0.55) | TP53LMNAMAPTGAAPOLB | |
| SCHEMBL5277732 | 0.80 | RAB9A (0.50) | TP53LMNAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | claimed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | claimed |