Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5305927 | 0.93 | BCHE (0.51) | ITGB1ITGA4BCHEACHEKDR | |
| SCHEMBL5307759 | 0.93 | KDR (0.44) | ITGB1ITGA4BCHEACHEKDR | |
| SCHEMBL5291502 | 0.90 | BCHE (0.46) | ITGB1ITGA4BCHEACHELMNA | |
| SCHEMBL2292763 | 0.88 | MAPT (0.50) | ALDH1A1LMNAMAPTHSD17B10KDM4E | |
| SCHEMBL5303427 | 0.87 | BCHE (0.51) | ITGB1ITGA4BCHEACHEKDR | |
| SCHEMBL2294905 | 0.86 | USP2 (0.51) | ALDH1A1LMNAMAPTPOLBMEN1 | |
| SCHEMBL2295247 | 0.86 | LMNA (0.50) | ALDH1A1TSHRLMNAMAPTKDM4E | |
| SCHEMBL2294482 | 0.86 | NAMPT (0.48) | ITGB1ITGA4ALDH1A1GAALMNA | |
| SCHEMBL5289381 | 0.85 | ITGB1 (0.44) | ITGB1ITGA4KDRMAPTKDM4E | |
| SCHEMBL2298594 | 0.84 | KMT2A (0.46) | ITGB1ITGA4ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |