Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL529253 | 0.88 | MAPK1 (0.58) | KMT2AKDM4EMEN1GAAMAPK1 | |
| SCHEMBL13692670 | 0.86 | KMT2A (0.69) | KMT2AKDM4EMEN1GAAMAPK1 | |
| SCHEMBL529115 | 0.84 | MELK (0.51) | KMT2AKDM4EMEN1GAAMAPK1 | |
| SCHEMBL530888 | 0.83 | KCNH2 (0.54) | KMT2AKDM4EMEN1GAACSF1R | |
| SCHEMBL531008 | 0.82 | KMT2A (0.46) | KMT2AKDM4EMEN1GAAPOLB | |
| SCHEMBL10282210 | 0.81 | MAPT (0.50) | KMT2AKDM4EMEN1GAACSF1R | |
| Hydrochloric Acid SCHEMBL529682 | 0.81 | MAPT (0.49) | KMT2AKDM4EMEN1GAACSF1R | |
| SCHEMBL530078 | 0.80 | KMT2A (0.44) | KMT2AKDM4EMEN1GAAMAPK1 | |
| SCHEMBL529687 | 0.79 | CSF1R (0.47) | KMT2AKDM4EMEN1GAACSF1R | |
| SCHEMBL529183 | 0.79 | MELK (0.52) | KMT2AKDM4EMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |