Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 4/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29764084 | 0.80 | MAPT (0.53) | IMPDH2IMPDH1FYNGAAMAPT | |
| SCHEMBL311721 | 0.80 | MAPT (0.53) | IMPDH2IMPDH1FYNGAAMAPT | |
| SCHEMBL15995418 | 0.79 | IMPDH2 (0.50) | IMPDH2IMPDH1 | |
| SCHEMBL3791216 | 0.78 | MAPT (0.52) | IMPDH2IMPDH1FYNGAAMAPT | |
| SCHEMBL347390 | 0.78 | MAPT (0.59) | IMPDH2IMPDH1GAAMAPTKDM4E | |
| SCHEMBL30839714 | 0.78 | MAPT (0.59) | IMPDH2IMPDH1GAAMAPTKDM4E | |
| SCHEMBL21180009 | 0.78 | NPC1 (0.39) | MAP4K4FYNALOX5APFEN1GAA | |
| SCHEMBL22446537 | 0.78 | PTGS2 (0.41) | MAP4K4FYNALOX5APFEN1FTO | |
| SCHEMBL15741689 | 0.76 | IMPDH2 (0.54) | IMPDH2IMPDH1GAAMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL10604756 | 0.76 | MAPT (0.57) | IMPDH2IMPDH1GAAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598481-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | Bristol-Myers Squibb Company (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012015723-A1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-02 | — | — | WO | disclosed |