Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 6/20 | 0.69 |
| ▸ | MMP2 | P08253 | 5/20 | 0.69 |
| ▸ | MMP9 | P14780 | 5/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 5/20 | 0.52 |
| ▸ | MAOA | P21397 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | NT5E | P21589 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28044570 | 0.86 | NPC1 (0.64) | ADAM17MMP2MMP9KDM4EALDH1A1 | |
| SCHEMBL13857135 | 0.84 | ADAM17 (0.70) | ADAM17MMP2MMP9KDM4EALDH1A1 | |
| SCHEMBL13857134 | 0.84 | ATM (0.67) | ADAM17MMP2MMP9KDM4EALDH1A1 | |
| SCHEMBL7537576 | 0.82 | MMP2 (0.72) | ADAM17MMP2MMP9KDM4EALDH1A1 | |
| SCHEMBL29089438 | 0.80 | ADAM17 (0.64) | ADAM17MMP2MMP9KDM4EALDH1A1 | |
| SCHEMBL27625488 | 0.80 | MMP2 (0.67) | ADAM17MMP2MMP9KDM4EALDH1A1 | |
| SCHEMBL31320649 | 0.77 | MMP2 (0.64) | ADAM17MMP2MMP9KDM4EALDH1A1 | |
| SCHEMBL11092927 | 0.77 | MAOB (0.66) | ADAM17MMP2MMP9KDM4EALDH1A1 | |
| SCHEMBL4927452 | 0.77 | MMP2 (0.64) | ADAM17MMP2MMP9KDM4EALDH1A1 | |
| SCHEMBL1285122 | 0.76 | MAOB (0.56) | ADAM17MMP2MMP9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124688-A1 | Prostaglandin reductase inhibitors | ABGENOMICS CORPORATION (TW) | 2009-05-14 | — | — | US | disclosed |
| US-20090124688-A1 | Prostaglandin reductase inhibitors | ABGENOMICS CORPORATION (TW) | 2009-05-14 | — | — | US | disclosed |
| WO-2007082178-A2 | PROSTAGLANDIN REDUCTASE INHIBITORS | ABGENOMICS CORPORATION (TW) | 2007-07-19 | — | — | WO | disclosed |
| WO-2007008037-A1 | NOVEL CHROMEN-2-ONE BASED HYDROXAMIC ACID DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY, THE PREPARATION THEREOF AND A COMPOSITION CONTAINING THE SAME FOR TREATING INFLAMMATORY DISEASE | JEIL PHARMACEUTICAL CO., LTD. (KR) | 2007-01-18 | — | — | WO | disclosed |
| WO-2007008037-A1 | NOVEL CHROMEN-2-ONE BASED HYDROXAMIC ACID DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY, THE PREPARATION THEREOF AND A COMPOSITION CONTAINING THE SAME FOR TREATING INFLAMMATORY DISEASE | JEIL PHARMACEUTICAL CO., LTD. (KR) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124688-A1 | Prostaglandin reductase inhibitors | PTGIR, PTGDR, PTGDR2 | ADAM17 3725/4885MMP2 929/4885MMP9 1646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.