Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.64 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.41 |
| ▸ | P4HA1 | P13674 | 3/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788261 | 0.86 | MGAM (0.64) | MGAMNAPRTHCAR2ALDH1A1APP | |
| Isoquinoline SCHEMBL28152444 | 0.84 | MGAM (0.77) | MGAMALDH1A1PSMD14MRGPRX4NPC1 | |
| SCHEMBL5314248 | 0.84 | HPGDS (0.51) | MGAMALDH1A1PSMD14CSNK2A2CSNK2B | |
| SCHEMBL29598071 | 0.80 | ALOX15 (0.54) | ALDH1A1GAAPSMD14CSNK2A2CSNK2B | |
| SCHEMBL12076107 | 0.80 | ALOX15 (0.54) | ALDH1A1GAAPSMD14CSNK2A2CSNK2B | |
| SCHEMBL10465639 | 0.79 | MGAM (0.70) | MGAMNAPRTALDH1A1GAAPSMD14 | |
| SCHEMBL529465 | 0.79 | MAP4K4 (0.63) | MGAMNAPRTCSNK2A2CSNK2B | |
| SCHEMBL29362407 | 0.78 | MGAM (1.00) | MGAMALDH1A1PSMD14NPC1RAB9A | |
| SCHEMBL28048 | 0.78 | MGAM (1.00) | MGAMALDH1A1PSMD14NPC1RAB9A | |
| SCHEMBL21945258 | 0.77 | MAOB (0.53) | ALDH1A1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12577243-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2026-03-17 | — | — | US | disclosed |
| EP-3856178-B1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2026-03-11 | — | — | EP | disclosed |
| EP-4541794-A1 | PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUNDS, AND PREPARATION AND USE THEREOF | Suzhong Pharmaceutical Group Co., Ltd. (CN) | 2025-04-23 | — | — | EP | disclosed |
| CN-119585263-A | Phenyl substituted dihydro Cai compounds and preparation and application thereof | 苏中药业集团股份有限公司 | 2025-03-07 | — | — | CN | disclosed |
| WO-2025011008-A1 | PHARMACEUTICAL PREPARATION CONTAINING PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUND, AND USE THEREOF | 苏中药业集团股份有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-119306715-A | Crystal of phenyl substituted dihydronaphthyridine compound and application thereof | 苏中药业集团股份有限公司 | 2025-01-14 | — | — | CN | disclosed |
| CN-119302952-A | Pharmaceutical preparation containing phenyl substituted dihydronaphthyridine compound and application thereof | 苏中药业集团股份有限公司 | 2025-01-14 | — | — | CN | disclosed |
| CN-118696036-A | PARP1 inhibitors | 突触活化疗法股份有限公司 | 2024-09-24 | — | — | CN | disclosed |
| US-12024518-B1 | Pyrazolo[4,3-C][1,6]naphthyridines as CK2 inhibitors | King Faisal University (SA) | 2024-07-02 | — | — | US | disclosed |
| WO-2024022481-A1 | PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUNDS, AND PREPARATION AND USE THEREOF | 苏中药业集团股份有限公司 | 2024-02-01 | — | — | WO | disclosed |
| WO-2021032687-A1 | ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES | UCB Biopharma SRL (BE) | 2021-02-25 | — | — | WO | disclosed |
| US-20200123152-A1 | Chemical Compounds as H-PGDS Inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-04-23 | — | — | US | disclosed |
| US-20200123152-A1 | Chemical Compounds as H-PGDS Inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-04-23 | — | — | US | disclosed |
| WO-2020065613-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-02 | — | — | WO | disclosed |
| US-20200102303-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-02 | — | — | US | disclosed |
| CN-110753692-A | Chemical compounds as H-PGDS inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-02-04 | — | — | CN | disclosed |
| CN-105612158-B | The somatostatin receptor hypotype 5 (SSTR5) antagonist | 武田药品工业株式会社 | 2017-06-30 | — | — | CN | disclosed |
| WO-2010112826-A2 | HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2010-10-07 | — | — | WO | disclosed |
| US-5039679-A | Cardiovascular disorders | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1991-08-13 | — | — | US | disclosed |
| US-5037987-A | Production of optical isomers of certain 1,6-naphthyridine-3-carboxylate derivatives | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1991-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123152-A1 | Chemical Compounds as H-PGDS Inhibitors | HPGDS, PTGS1, PTGIS | MGAM 3026/4885NAPRT 2240/4885HCAR2 453/4885 |
| US-12577243-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, FAAH | MGAM 863/4885NAPRT 3732/4885HCAR2 702/4885 |
| US-20200102303-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | MGAM 163/4885NAPRT 3147/4885HCAR2 1119/4885 |
| US-12024518-B1 | Pyrazolo[4,3-C][1,6]naphthyridines as CK2 inhibitors | CSNK2A3, CSNK1A1, CSNK1G3 | MGAM 4357/4885NAPRT 1428/4885HCAR2 3904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.