Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL528849 | 0.91 | MAPT (0.73) | MAPTHTTLMNASMN1; SMN2KDM4E | |
| SCHEMBL528488 | 0.89 | MAPT (0.64) | MAPTHTTLMNAKDM4EALDH1A1 | |
| SCHEMBL528834 | 0.87 | MAPT (0.62) | MAPTHTTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL527908 | 0.87 | MAPT (0.61) | MAPTHTTLMNAKDM4EALDH1A1 | |
| SCHEMBL528264 | 0.86 | MAPT (0.60) | MAPTHTTLMNAPOLBKDM4E | |
| SCHEMBL528625 | 0.82 | MAPT (0.54) | MAPTHTTLMNASMN1; SMN2KDM4E | |
| SCHEMBL528500 | 0.81 | MAPT (0.77) | MAPTHTTLMNASMN1; SMN2KDM4E | |
| SCHEMBL528224 | 0.80 | ALDH1A1 (0.56) | MAPTHTTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL528717 | 0.80 | MAPT (0.76) | MAPTHTTLMNASMN1; SMN2KDM4E | |
| SCHEMBL528788 | 0.80 | MAPT (0.54) | MAPTHTTLMNAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014127-A1 | 5-LIPOXYGENASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2012-02-02 | — | — | WO | disclosed |