Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3912410 | 0.90 | PDE10A (0.56) | MEN1KMT2ADHODHTSHRSMN1; SMN2 | |
| SCHEMBL8807038 | 0.85 | SMN1; SMN2 (0.56) | MEN1KMT2ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL5458072 | 0.84 | DHODH (0.54) | DHODHTSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1902570 | 0.80 | LMNA (0.47) | DHODHTSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL27720177 | 0.80 | PDE10A (0.56) | MEN1KMT2ADHODHTSHRSMN1; SMN2 | |
| SCHEMBL327089 | 0.78 | IKBKB (0.63) | MEN1KMT2ADHODHTSHRSMN1; SMN2 | |
| SCHEMBL30499579 | 0.78 | IKBKB (0.63) | MEN1KMT2ADHODHTSHRSMN1; SMN2 | |
| SCHEMBL9866667 | 0.77 | L3MBTL1 (0.62) | MEN1KMT2APOLBDHODHSMN1; SMN2 | |
| SCHEMBL31133499 | 0.76 | IKBKB (0.51) | MEN1KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL352221 | 0.76 | IKBKB (0.51) | MEN1KMT2APOLBTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |