Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Phthalimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 5/20 | 0.56 |
| ▸ | CASP7 | P55210 | 3/20 | 0.56 |
| ▸ | CASP6 | P55212 | 3/20 | 0.56 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.56 |
| ▸ | CASP2 | P42575 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 2/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalimide SCHEMBL6673556 | 0.92 | GSK3B (0.60) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL31512165 | 0.91 | GSK3B (0.54) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL6240148 | 0.88 | GSK3B (0.56) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL28860413 | 0.87 | GSK3B (0.65) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL15488735 | 0.86 | GSK3B (0.79) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL28321102 | 0.85 | ALDH1A1 (0.52) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL28152335 | 0.85 | GSK3B (0.62) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL28399928 | 0.85 | GSK3B (0.62) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL7297919 | 0.84 | GSK3B (0.75) | GSK3BCASP3CASP7CASP6CASP8 | |
| Phthalimide SCHEMBL27689724 | 0.84 | AKR1B1 (0.53) | GSK3BHSD17B10KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010504-A2 | ACID ADDITION SALTS OF ISOINDOLES ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | disclosed |