Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 4/20 | 0.54 |
| ▸ | CASP2 | P42575 | 2/20 | 0.52 |
| ▸ | CASP7 | P55210 | 2/20 | 0.52 |
| ▸ | CASP6 | P55212 | 2/20 | 0.52 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalimide SCHEMBL5300476 | 0.92 | GSK3B (0.65) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL28321102 | 0.89 | ALDH1A1 (0.52) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL27689724 | 0.88 | AKR1B1 (0.53) | GSK3BHDAC11MAPTALDH1A1SLC22A6 | |
| Phthalimide SCHEMBL6240148 | 0.85 | GSK3B (0.56) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL28860413 | 0.83 | GSK3B (0.65) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL31512165 | 0.83 | GSK3B (0.54) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL15488735 | 0.83 | GSK3B (0.79) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL28152335 | 0.82 | GSK3B (0.62) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL28399928 | 0.82 | GSK3B (0.62) | GSK3BCASP3CASP2CASP7CASP6 | |
| Phthalimide SCHEMBL7297919 | 0.81 | GSK3B (0.75) | GSK3BCASP3CASP2CASP7CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0955310-B1 | New derivatives of (3,4,7,8,9,10)-hexahydro-6,10-dioxo-6H-pyridazino /1,2-a/ /1,2/ diazepine-1-carboxylic acid, process for their preparation and use for preparation of pharmaceutical agents | AVENTIS PHARMA SA (FR) | 2004-10-13 | — | — | EP | disclosed |
| EP-0955310-A1 | New derivatives of (3,4,7,8,9,10)-hexahydro-6,10-dioxo-6H-pyridazino /1,2-a/ /1,2/ diazepine-1-carboxylic acid, process for their preparation and use for preparation of pharmaceutical agents | HOECHST MARION ROUSSEL (FR) | 1999-11-10 | — | — | EP | disclosed |