Phthalimide

Phthalimide

SCHEMBL28860413

O=C(O)CC(=O)O.O=C1NC(=O)c2ccccc21

nearest known ligand 0.65

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.65
CASP3 P42574 7/20 0.56
CASP2 P42575 2/20 0.56
CASP7 P55210 2/20 0.56
CASP6 P55212 2/20 0.56
CASP8 Q14790 2/20 0.56
ALDH1A1 P00352 4/20 0.46
KDM4E B2RXH2 3/20 0.46
LMNA P02545 2/20 0.46
MAPK1 P28482 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
KMT2A Q03164 2/20 0.46
HSD17B10 Q99714 2/20 0.46
HPGD P15428 2/20 0.46
MAPT P10636 2/20 0.46
MEN1 O00255 1/20 0.46
RGS12 O14924 1/20 0.46
GMNN O75496 1/20 0.46
PRKD3 O94806 1/20 0.46
EGFR P00533 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phthalimide SCHEMBL5300476 0.87 GSK3B (0.65) GSK3BCASP3CASP2CASP7CASP6
Phthalimide SCHEMBL15488735 0.86 GSK3B (0.79) GSK3BCASP3CASP2CASP7CASP6
Phthalimide SCHEMBL28152335 0.85 GSK3B (0.62) GSK3BCASP3CASP2CASP7CASP6
Phthalimide SCHEMBL28399928 0.85 GSK3B (0.62) GSK3BCASP3CASP2CASP7CASP6
Phthalimide SCHEMBL7297919 0.84 GSK3B (0.75) GSK3BCASP3CASP2CASP7CASP6
Phthalimide SCHEMBL6673556 0.83 GSK3B (0.60) GSK3BCASP3CASP2CASP7CASP6
Phthalimide SCHEMBL3984602 0.83 GSK3B (0.94) GSK3BCASP3CASP2CASP7CASP6
Phthalimide SCHEMBL30452542 0.82 GSK3B (0.71) GSK3BCASP3CASP2CASP7CASP6
Phthalimide SCHEMBL4318901 0.82 GSK3B (0.71) GSK3BCASP3CASP2CASP7CASP6
Phthalimide SCHEMBL11040503 0.81 GSK3B (1.00) GSK3BCASP3CASP2CASP7CASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108299281-A A kind of synthetic method of the deuterium-labeled a-amino acid of stable isotope 上海化工研究院有限公司 2018-07-20 CN claimed
CN-108299281-A A kind of synthetic method of the deuterium-labeled a-amino acid of stable isotope 上海化工研究院有限公司 2018-07-20 CN disclosed