Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4900234 | 0.97 | TSHR (0.36) | TSHRVCPMCL1MAOBGHSR | |
| SCHEMBL4898932 | 0.85 | VCP (0.36) | TSHRVCPMCL1MAOBGHSR | |
| SCHEMBL4899994 | 0.84 | TSHR (0.37) | TSHRVCPMAOBGHSRMAPT | |
| SCHEMBL6966496 | 0.82 | VCP (0.37) | TSHRVCPTP53MAPTACSS2 | |
| SCHEMBL6960428 | 0.82 | VCP (0.37) | TSHRVCPACSS2 | |
| SCHEMBL5243251 | 0.82 | HTR2C (0.32) | TLR7HTR2C | |
| SCHEMBL4901053 | 0.81 | TSHR (0.37) | TSHRMAOBGHSRACSS2HTR2C | |
| SCHEMBL4902092 | 0.81 | TSHR (0.35) | TSHRMAOBGHSRACSS2HTR2C | |
| SCHEMBL6960598 | 0.79 | TDP1 (0.36) | TSHRVCPTP53 | |
| SCHEMBL6957486 | 0.79 | VCP (0.36) | TSHRVCPTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740550-A1 | SULPHUR-LINKED IMIDAZOLE COMPOUNDS FOR THE TREAMENT OF HIV | Pfizer Limited (GB) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005100322-A1 | SULPHUR-LINKED IMIDAZOLE COMPOUNDS FOR THE TREAMENT OF HIV | PFIZER LIMITED (GB) | 2005-10-27 | — | — | WO | disclosed |