SCHEMBL6957486

SCHEMBL6957486

CCn1c(COCc2ccccc2)nc(C(C)C)c1Sc1cccc(F)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VCP P55072 2/20 0.36
SLC6A9 P48067 4/20 0.34
DHODH Q02127 2/20 0.33
KMT2A Q03164 1/20 0.33
ATM Q13315 1/20 0.33
PTGS1 P23219 1/20 0.32
PTGS2 P35354 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
HTT P42858 2/20 0.31
TSHR P16473 1/20 0.31
MAPT P10636 2/20 0.31
DHFR P00374 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
HPGD P15428 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
NPSR1 Q6W5P4 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6960428 0.92 VCP (0.37) VCPDHODHKMT2ATSHR
SCHEMBL6960598 0.88 TDP1 (0.36) VCPSLC6A9KMT2ATSHRLMNA
SCHEMBL7081196 0.86 DHODH (0.35) VCPSLC6A9DHODHDHFR
SCHEMBL6962522 0.85 CYP2C9 (0.40) KMT2ASMN1; SMN2MAPTALDH1A1LMNA
SCHEMBL6966496 0.84 VCP (0.37) VCPDHODHSMN1; SMN2TSHRMAPT
SCHEMBL6974491 0.82 MEN1 (0.37) SLC6A9DHODHKMT2AMAPTDHFR
SCHEMBL7084536 0.82 DHODH (0.33) SLC6A9DHODHKMT2AMAPTALDH1A1
SCHEMBL6974771 0.82 DHODH (0.43) SLC6A9DHODHKMT2AATMMAPT
SCHEMBL7086664 0.82 DHODH (0.35) SLC6A9DHODHKMT2AATMMAPT
SCHEMBL7087212 0.81 EPHX1 (0.33) SLC6A9DHODHKMT2AMAPTDHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed