Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5294631 | 0.93 | MEN1 (0.51) | KMT2AMEN1SMN1; SMN2HPGDLMNA | |
| SCHEMBL2295562 | 0.91 | LMNA (0.48) | KMT2AMEN1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL2297605 | 0.88 | SMN1; SMN2 (0.52) | KMT2AMEN1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL2291248 | 0.86 | USP2 (0.51) | KMT2AMEN1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL5303427 | 0.85 | BCHE (0.51) | KMT2AMEN1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL2295247 | 0.84 | LMNA (0.50) | KMT2AMEN1SMN1; SMN2HPGDLMNA | |
| SCHEMBL5300999 | 0.84 | SMN1; SMN2 (0.50) | KMT2AMEN1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL2295280 | 0.83 | KMT2A (0.50) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5307759 | 0.83 | KDR (0.44) | KMT2AMEN1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL2299767 | 0.83 | SMN1; SMN2 (0.51) | KMT2AMEN1SMN1; SMN2HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |