Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5289524 | 0.93 | ITGB1 (0.44) | KDRITGB1ITGA4BCHEACHE | |
| SCHEMBL5303427 | 0.93 | BCHE (0.51) | KDRITGB1ITGA4BCHEACHE | |
| SCHEMBL5295744 | 0.90 | BCHE (0.46) | ITGB1ITGA4BCHEACHENPC1 | |
| SCHEMBL2297605 | 0.88 | SMN1; SMN2 (0.52) | KDRNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL5305927 | 0.87 | BCHE (0.51) | KDRITGB1ITGA4BCHEACHE | |
| SCHEMBL2291248 | 0.86 | USP2 (0.51) | NPC1LMNARAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2295562 | 0.86 | LMNA (0.48) | NPC1LMNARAB9ASMN1; SMN2ADRA2B | |
| SCHEMBL2291392 | 0.86 | KMT2A (0.51) | NPC1LMNARAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5305129 | 0.85 | NPC1 (0.49) | KDRITGB1ITGA4NPC1LMNA | |
| SCHEMBL2297135 | 0.84 | KMT2A (0.46) | ITGB1ITGA4NPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |