Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | XPO1 | O14980 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ATF1 | P18846 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23214098 | 0.81 | ALDH1A1 (0.40) | CCR2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2511068 | 0.77 | KMT2A (0.52) | XPO1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7230088 | 0.77 | POLB (0.34) | GRM4RIPK1MAPTALDH1A1DYRK1A | |
| SCHEMBL7229990 | 0.77 | RIPK1 (0.34) | MEN1KMT2AATF1NFKB1GRM4 | |
| SCHEMBL18010978 | 0.76 | RIPK1 (0.35) | CCR2MEN1KMT2AATF1NFKB1 | |
| SCHEMBL3810678 | 0.74 | MAPT (0.39) | CCR2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3823010 | 0.74 | RAB9A (0.44) | CCR2MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL7239127 | 0.73 | GRM5 (0.54) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL16636659 | 0.73 | MEN1 (0.36) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL20481515 | 0.72 | ATF1 (0.38) | CCR2XPO1MEN1KMT2AATF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710224-B2 | Heterocyclic compounds as CCR2B antagonists | ASTRAZENECA AB (SE) | 2014-04-29 | — | — | US | disclosed |
| EP-1831164-A1 | HETEROCYCLIC COMPOUNDS AS CCR2B ANTAGONISTS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067401-A1 | HETEROCYCLIC COMPOUNDS AS CCR2B ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |