Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5294571 | 0.88 | HCAR2 (0.71) | RAB9ANPC1HCAR2KDM4EPOLB | |
| SCHEMBL5061069 | 0.86 | RAB9A (0.86) | RAB9ANPC1HCAR2KDM4EPOLB | |
| SCHEMBL5309261 | 0.84 | HCAR2 (0.60) | RAB9ANPC1HCAR2KMT2ASMN1; SMN2 | |
| SCHEMBL14609699 | 0.83 | HCAR2 (0.64) | RAB9ANPC1HCAR2KDM4EKMT2A | |
| SCHEMBL5307210 | 0.79 | NPC1 (0.69) | RAB9ANPC1HCAR2KDM4EPOLB | |
| SCHEMBL5296521 | 0.79 | NPC1 (0.77) | RAB9ANPC1HCAR2KDM4EPOLB | |
| SCHEMBL12646487 | 0.78 | HCAR2 (0.57) | HCAR2KDM4ECYP2C9SMN1; SMN2ALDH1A1 | |
| SCHEMBL4749629 | 0.78 | NPC1 (0.61) | RAB9ANPC1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL5292909 | 0.77 | HCAR2 (0.69) | RAB9ANPC1HCAR2KDM4EKMT2A | |
| SCHEMBL4752208 | 0.75 | LMNA (0.69) | RAB9ANPC1POLBKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |