Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5292909 | 0.89 | HCAR2 (0.69) | HCAR2MAPK8MAPK10ALDH1A1KMT2A | |
| SCHEMBL5303546 | 0.86 | MAPK8 (0.66) | HCAR2MAPK8MAPK10MAPK9HTT | |
| SCHEMBL5301445 | 0.84 | RAB9A (0.70) | HCAR2ALDH1A1SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL14609699 | 0.82 | HCAR2 (0.64) | HCAR2MAPK8MAPK10MAPK9ALDH1A1 | |
| SCHEMBL5330467 | 0.80 | KMT2A (0.60) | MAPK8MAPK10MAPK9ALDH1A1HTT | |
| SCHEMBL5292231 | 0.79 | LMNA (0.57) | MAPK8MAPK10MAPK9ALDH1A1HTT | |
| SCHEMBL5301746 | 0.79 | KMT2A (0.77) | MAPK8MAPK10MAPK9ALDH1A1HTT | |
| SCHEMBL5292551 | 0.79 | POLB (0.61) | MAPK8MAPK10MAPK9ALDH1A1HTT | |
| SCHEMBL5303540 | 0.79 | SMN1; SMN2 (0.54) | MAPK8MAPK10MAPK9ALDH1A1HTT | |
| SCHEMBL4749274 | 0.78 | SMN1; SMN2 (0.56) | MAPK8MAPK10MAPK9ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |