Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 7/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30289956 | 0.91 | F12 (0.47) | F12 | |
| SCHEMBL2335872 | 0.91 | F12 (0.47) | F12 | |
| SCHEMBL6629846 | 0.81 | KCNH2 (0.50) | KCNH2ALDH1A1 | |
| SCHEMBL7377538 | 0.81 | ALDH1A1 (0.51) | F12CYP1A2KCNH2POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL2258244 | 0.80 | KCNH2 (0.49) | KCNH2ALDH1A1 | |
| SCHEMBL6671303 | 0.79 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL6601659 | 0.76 | EGFR (0.48) | — | |
| SCHEMBL27544373 | 0.75 | F12 (0.44) | F12 | |
| SCHEMBL769134 | 0.74 | KMT2A (0.51) | ALDH1A1MEN1KMT2A | |
| SCHEMBL29484101 | 0.74 | KMT2A (0.51) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799684-A2 | LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006041773-A2 | LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-04-20 | — | — | WO | disclosed |