Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | IDE | P14735 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2297594 | 0.93 | PRNP (0.41) | PRNPL3MBTL1SMN1; SMN2TP53MAPT | |
| SCHEMBL2297333 | 0.89 | ADRA2B (0.49) | PRNPL3MBTL1SMN1; SMN2TP53MAPT | |
| SCHEMBL2292853 | 0.87 | ALDH1A1 (0.47) | PRNPL3MBTL1SMN1; SMN2TP53MAPT | |
| SCHEMBL2358248 | 0.83 | SMN1; SMN2 (0.45) | L3MBTL1SMN1; SMN2MAPTADRA2BNPC1 | |
| SCHEMBL5294462 | 0.82 | NPC1 (0.43) | PRNPL3MBTL1SMN1; SMN2TP53MAPT | |
| SCHEMBL2294395 | 0.82 | MAPT (0.46) | SMN1; SMN2MAPTADRA2BRAB9ALMNA | |
| SCHEMBL5287546 | 0.81 | ADRA2B (0.47) | PRNPL3MBTL1SMN1; SMN2TP53MAPT | |
| SCHEMBL5280673 | 0.81 | ADRA2B (0.52) | PRNPL3MBTL1SMN1; SMN2TP53MAPT | |
| SCHEMBL12421961 | 0.81 | ADRA2B (0.50) | PRNPL3MBTL1SMN1; SMN2TP53MAPT | |
| SCHEMBL2296307 | 0.81 | NPC1 (0.46) | SMN1; SMN2TP53MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828144-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI Pharmaceuticals, Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006053342-A2 | INTEGRIN ANTAGONISTS USEFUL AS ANTICANCER AGENTS | OSI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |