Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5295488 | 0.90 | HCAR2 (0.48) | KDM4EMAPK8MAPK10MAPTMAPK9 | |
| SCHEMBL5301758 | 0.88 | HCAR2 (0.52) | HDAC1HDAC6HCAR2 | |
| SCHEMBL5061223 | 0.86 | KDM4E (0.62) | KDM4EMAPK8MAPK10MAPK9NPC1 | |
| SCHEMBL5300760 | 0.85 | ALDH1A1 (0.56) | KDM4EMAPK8MAPK10POLBMAPT | |
| SCHEMBL5300553 | 0.85 | KDM4E (0.49) | KDM4EMAPK8MAPK10POLBMAPK9 | |
| SCHEMBL5303071 | 0.84 | KDM4E (0.50) | KDM4EMAPK8MAPK10MAPK9NPC1 | |
| SCHEMBL5302379 | 0.82 | KDM4E (0.54) | KDM4EMAPK8MAPK10POLBMAPK9 | |
| SCHEMBL5292551 | 0.81 | POLB (0.61) | MAPK8MAPK10POLBMAPTMAPK9 | |
| SCHEMBL5296892 | 0.80 | HCAR2 (0.67) | KDM4EMAPK8MAPK10MAPK9RAB9A | |
| SCHEMBL5301602 | 0.80 | KDM4E (0.50) | KDM4EMAPK8MAPK10MAPTMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |