Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5462183 | 0.87 | NPC1 (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5065123 | 0.85 | NPC1 (0.64) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4753018 | 0.81 | ALDH1A1 (0.80) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL34468530 | 0.80 | MAPT (0.59) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5296521 | 0.80 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL4753019 | 0.79 | ALDH1A1 (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4753012 | 0.78 | KMT2A (0.63) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4749278 | 0.77 | NPC1 (0.55) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4752212 | 0.75 | NPC1 (0.67) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7930548 | 0.75 | KMT2A (0.63) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |