Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 4/20 | 0.49 |
| ▸ | KLK7 | P49862 | 2/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.47 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 4/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8243065 | 1.00 | MAPT (0.51) | MAPTPOLBMAPK1PTGER4CTSL | |
| SCHEMBL8242070 | 0.92 | MAPT (0.59) | MAPTPOLBMAPK1PTGER4CTSL | |
| SCHEMBL5302755 | 0.92 | MAPT (0.59) | MAPTPOLBMAPK1PTGER4CTSL | |
| SCHEMBL5307097 | 0.92 | PTGER4 (0.56) | PTGER4CTSLALDH1A1CTSSCTSB | |
| SCHEMBL5297597 | 0.92 | MEN1 (0.53) | CTSLKLK7KLK5PSMB5CTSS | |
| SCHEMBL8237024 | 0.92 | MEN1 (0.53) | CTSLKLK7KLK5PSMB5CTSS | |
| SCHEMBL5308378 | 0.90 | PAX8 (0.57) | MAPTPOLBMAPK1PTGER4CTSL | |
| SCHEMBL5303739 | 0.89 | MAPT (0.54) | MAPTPOLBMAPK1PTGER4CTSL | |
| SCHEMBL8242759 | 0.89 | MAPT (0.54) | MAPTPOLBMAPK1PTGER4CTSL | |
| SCHEMBL5309738 | 0.89 | MAPT (0.53) | MAPTPOLBMAPK1PTGER4CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007027742-A2 | SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-03-08 | — | — | WO | claimed |
| WO-2007027742-A2 | SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-03-08 | — | — | WO | disclosed |