SCHEMBL530312

SCHEMBL530312

NC(=O)C=Cc1ccccc1Nc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 6/20 0.48
SIRT1 Q96EB6 3/20 0.45
FABP4 P15090 1/20 0.45
MAPT P10636 6/20 0.43
GAA P10253 4/20 0.43
GFER P55789 1/20 0.43
KDM4E B2RXH2 3/20 0.43
ALDH1A1 P00352 2/20 0.43
MAOB P27338 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
LMNA P02545 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
PTPN1 P18031 2/20 0.43
ALOX15 P16050 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL530136 0.88 BRD4 (0.44) SIRT2SIRT1FABP4MAPTGAA
SCHEMBL11829602 0.86 CA1 (0.55) SIRT2SIRT1FABP4MAPTGAA
SCHEMBL11829593 0.86 CA1 (0.55) SIRT2SIRT1FABP4MAPTGAA
SCHEMBL18632070 0.81 SIRT2 (0.52) SIRT2SIRT1FABP4MAPTKDM4E
SCHEMBL18632071 0.81 SIRT2 (0.52) SIRT2SIRT1FABP4MAPTKDM4E
SCHEMBL27500811 0.78 PTPN1 (0.43) MAPTGAAKDM4EALDH1A1MEN1
SCHEMBL2328371 0.78 NFKB1 (0.50) MAPTKDM4ELMNAPTPN1CA1
SCHEMBL291040 0.77 MAPT (0.40) SIRT2FABP4MAPTGAAKDM4E
SCHEMBL291417 0.77 FABP4 (0.41) SIRT2FABP4MAPTGAAKDM4E
SCHEMBL291416 0.77 FABP4 (0.41) SIRT2FABP4MAPTGAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2792733-B1 FRICTION AND WEAR REDUCING AGENT FOR LUBRICATING OIL AND LUBRICATING OIL COMPOSITION CONTAINING SAME ADEKA CORP (JP) 2017-03-15 EP disclosed
US-20150299604-A1 FRICTION AND WEAR REDUCING AGENT FOR LUBRICATING OIL AND LUBRICATING OIL COMPOSITION CONTAINING SAME ADEKA CORPORATION (JP) 2015-10-22 US disclosed
EP-2792733-A1 FRICTION AND WEAR REDUCING AGENT FOR LUBRICATING OIL AND LUBRICATING OIL COMPOSITION CONTAINING SAME Adeka Corporation (JP) 2014-10-22 EP disclosed
EP-2598825-A2 BALLISTIC SHIELD COMPOSITES WITH ENHANCED FRAGMENT RESISTANCE Honeywell International, Inc. (US) 2013-06-05 EP disclosed
WO-2012015680-A2 BALLISTIC SHIELD COMPOSITES WITH ENHANCED FRAGMENT RESISTANCE HONEYWELL INTERNATIONAL INC. (US) 2012-02-02 WO disclosed