Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3916812 | 0.80 | PDK2 (0.59) | CNR2HTTPDK2HSD17B1HSD17B2 | |
| SCHEMBL5309035 | 0.77 | MEN1 (0.51) | CNR2HTTLMNAALDH1A1POLB | |
| SCHEMBL4961925 | 0.76 | CNR2 (0.47) | CNR2HTTPDK2HSD17B1HSD17B2 | |
| SCHEMBL27771335 | 0.73 | CNR2 (0.44) | CNR2HTTPDK2HSD17B1HSD17B2 | |
| SCHEMBL6424264 | 0.73 | PDK2 (0.56) | CNR2PDK2HSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL14174832 | 0.73 | HTT (0.61) | CNR2HTTPDK2NR1H4CNR1 | |
| SCHEMBL4966178 | 0.73 | CNR2 (0.60) | CNR2HTTNR1H4LMNACNR1 | |
| SCHEMBL6420648 | 0.73 | HTT (0.43) | CNR2HTTPDK2HSD17B1HSD17B2 | |
| SCHEMBL5086341 | 0.72 | CNR2 (0.56) | CNR2PDK2HSD17B1HSD17B2CNR1 | |
| SCHEMBL5133736 | 0.72 | CNR2 (0.49) | CNR2HTTPDK2HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007041593-A2 | ANTI-SCARRING DRUG COMBINATIONS AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2005079284-A2 | METHODS AND REAGENTS FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH INCREASED LEVELS OF PROINFLAMMATORY CYTOKINES | COMBINATORX, INCORPORATED (US) | 2005-09-01 | — | — | WO | disclosed |