Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5305249 | 0.76 | CNR2 (0.51) | CNR2HTTPDK2GPR88NR1H4 | |
| SCHEMBL3916812 | 0.72 | PDK2 (0.59) | CNR2HTTPDK2HSD17B1HSD17B2 | |
| SCHEMBL27771335 | 0.69 | CNR2 (0.44) | CNR2HTTPDK2CYP3A4HSD17B1 | |
| SCHEMBL4966178 | 0.69 | CNR2 (0.60) | CNR2HTTNR1H4CNR1LMNA | |
| SCHEMBL6420648 | 0.68 | HTT (0.43) | CNR2HTTPDK2CYP3A4CNR1 | |
| SCHEMBL4970084 | 0.68 | HTT (0.44) | CNR2HTTPDK2NR1H4MEN1 | |
| SCHEMBL5133736 | 0.68 | CNR2 (0.49) | CNR2HTTPDK2NR1H4CYP3A4 | |
| SCHEMBL4963412 | 0.68 | HTT (0.55) | CNR2HTTGPR88MEN1KMT2A | |
| SCHEMBL4969869 | 0.68 | HTT (0.63) | CNR2HTTCNR1MEN1KMT2A | |
| SCHEMBL4961889 | 0.68 | HTT (0.51) | CNR2HTTPDK2NR1H4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773780-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1773780-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012227-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | claimed |
| EP-1773780-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1773780-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006012227-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |