Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5305249 | 0.72 | CNR2 (0.51) | CNR2HTTALDH1A1NR1H4CNR1 | |
| SCHEMBL4961973 | 0.69 | CHRM2 (0.49) | CNR2HTTALDH1A1POLBMAPT | |
| SCHEMBL4961925 | 0.68 | CNR2 (0.47) | CNR2HTTNR1H4CNR1CYP3A4 | |
| SCHEMBL4966178 | 0.68 | CNR2 (0.60) | CNR2HTTNR1H4CNR1MAPT | |
| SCHEMBL6420648 | 0.67 | HTT (0.43) | CNR2HTTALDH1A1CNR1POLB | |
| SCHEMBL3916812 | 0.67 | PDK2 (0.59) | CNR2HTTALDH1A1POLBPDK2 | |
| SCHEMBL5131364 | 0.67 | PTGS1 (0.53) | POLBSLC18A3RAB9ALMNA | |
| SCHEMBL5086341 | 0.67 | CNR2 (0.56) | CNR2CNR1POLBSMN1; SMN2PDK2 | |
| SCHEMBL6425135 | 0.67 | CNR2 (0.52) | CNR2ALDH1A1NR1H4CNR1POLB | |
| SCHEMBL4961889 | 0.67 | HTT (0.51) | CNR2HTTALDH1A1NR1H4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773780-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1773780-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006012227-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |