Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acemetacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 14/20 | 0.96 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.96 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.96 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.96 |
| ▸ | HTR1A | P08908 | 1/20 | 0.96 |
| ▸ | PKM | P14618 | 1/20 | 0.96 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.85 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.85 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.85 |
| ▸ | MEN1 | O00255 | 1/20 | 0.85 |
| ▸ | PTGES | O14684 | 1/20 | 0.85 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.85 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.85 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.85 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.85 |
| ▸ | ALB | P02768 | 1/20 | 0.85 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.85 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acemetacin SCHEMBL23843 | 0.98 | PTGS2 (1.00) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Acemetacin SCHEMBL29402955 | 0.98 | PTGS2 (1.00) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Acemetacin SCHEMBL5400266 | 0.97 | PTGS2 (0.98) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Acemetacin SCHEMBL10910170 | 0.97 | PTGS2 (0.98) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Indomethacin SCHEMBL29525957 | 0.92 | PTGS2 (1.00) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Indomethacin SCHEMBL29353712 | 0.92 | PTGS2 (1.00) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Indomethacin SCHEMBL3518614 | 0.92 | PTGS2 (1.00) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Indomethacin SCHEMBL9300 | 0.92 | PTGS2 (1.00) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Acemetacin SCHEMBL11002947 | 0.92 | PTGS2 (0.88) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Indomethacin SCHEMBL23391006 | 0.91 | PTGS2 (0.98) | PTGS2PTGS1GLO1HIF1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109843-A1 | METAL COMPLEXES HAVING ANTI-INFLAMMATORY ACTIVITY | MEDICAL THERAPIES LIMITED (AU) | 2007-10-04 | — | — | WO | disclosed |
| WO-2007110755-A1 | PROPHYLAXIS OR TREATMENT OF CARDIOVASCULAR INFLAMMATION | MEDICAL THERAPIES LIMITED (AU) | 2007-10-04 | — | — | WO | disclosed |
| WO-2007109844-A1 | ANTI-INFLAMMATORY METAL COMPLEXES | MEDICAL THERAPIES LIMITED (AU) | 2007-10-04 | — | — | WO | disclosed |
| WO-2007109845-A1 | PROPHYLAXIS OR TREATMENT OF DIABETES | MEDICAL THERAPIES LIMITED (AU) | 2007-10-04 | — | — | WO | disclosed |
| WO-2007110745-A1 | COMBINATION THERAPY FOR TREATMENT OF CANCER | MEDICAL THERAPIES LIMITED (AU) | 2007-10-04 | — | — | WO | disclosed |
| WO-2007026240-A1 | SUNSCREEN AND COSMETIC COMPOSITIONS FOR PROPHYLAXIS OR TREATMENT OF SKIN CANCERS | MEDICAL THERAPIES LIMITED (AU) | 2007-03-08 | — | — | WO | disclosed |
| WO-2006099685-A1 | METHOD FOR THE PROPHYLAXIS OR TREATMENT OF CARCINOMAS | MEDICAL THERAPIES LIMITED (AU) | 2006-09-28 | — | — | WO | disclosed |