Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acemetacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 16/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 1.00 |
| ▸ | GLO1 | Q04760 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.81 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | PTGES | O14684 | 1/20 | 0.81 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.81 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.81 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | ALB | P02768 | 1/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.81 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.81 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acemetacin SCHEMBL29402955 | 1.00 | PTGS2 (1.00) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Acemetacin SCHEMBL10910170 | 0.99 | PTGS2 (0.98) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Acemetacin SCHEMBL5400266 | 0.99 | PTGS2 (0.98) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Acemetacin SCHEMBL5306430 | 0.98 | PTGS2 (0.96) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| Acemetacin SCHEMBL11002947 | 0.94 | PTGS2 (0.88) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| SCHEMBL12609003 | 0.92 | PTGS2 (0.85) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| SCHEMBL9654237 | 0.91 | PTGS2 (0.84) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| SCHEMBL13802251 | 0.91 | PTGS2 (0.84) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| SCHEMBL4549122 | 0.91 | PTGS2 (1.00) | PTGS2PTGS1GLO1HIF1AHTR1A | |
| SCHEMBL10909072 | 0.91 | PTGS2 (0.83) | PTGS2PTGS1GLO1HIF1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 18318 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| EP-4674894-A2 | COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES | Hemoteq AG (DE) | 2026-01-07 | — | — | EP | claimed |
| EP-4662203-A1 | BINDARIT CONJUGATES, COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES OR DISORDERS | Translatum Medicus Inc. (CA) | 2025-12-17 | — | — | EP | claimed |
| EP-4663688-A2 | CROSSLINKERS | Hemoteq AG (DE) | 2025-12-17 | — | — | EP | claimed |
| EP-4628080-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Jeil Pharmaceutical Co., Ltd. (KR) | 2025-10-08 | — | — | EP | claimed |
| US-20250255781-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-14 | — | — | US | claimed |
| CN-120124965-A | Method and medium for determining and classifying adjustment capacity requirements | 国网山西省电力公司电力科学研究院 | 2025-06-10 | — | — | CN | claimed |
| US-12296043-B2 | Liquisoft capsules | PATHEON SOFTGELS INC. (US) | 2025-05-13 | — | — | US | claimed |
| CN-119757554-A | High performance liquid chromatography-tandem mass spectrometry analysis method for simultaneously detecting 33 components of anti-inflammatory agent in cosmetics | 四川省药品检验研究院(四川省医疗器械检测中心) | 2025-04-04 | — | — | CN | claimed |
| WO-2025062440-A1 | TOPICAL NANO-DISPERSION COMPOSITIONS AND THEIR PREPARATION THEREOF | PULSE PHARMACEUTICALS PVT. LTD (IN) | 2025-03-27 | — | — | WO | claimed |
| WO-1985004589-A1 | COUGH/COLD MIXTURES COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | SUNSHINE ABRAHAM | 1985-10-24 | — | — | WO | claimed |
| WO-1985003443-A1 | ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING DIPHENHYDRAMINE AND METHODS OF USING SAME | RICHARDSON-VICKS, INC. (US) | 1985-08-15 | — | — | WO | claimed |
| WO-1985002542-A1 | ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1985-06-20 | — | — | WO | claimed |
| EP-0132690-A1 | Thermoplastics containing antiphlogistics | Troponwerke GmbH & Co. KG (DE) | 1985-02-13 | — | — | EP | claimed |
| EP-0126942-A1 | Preparation process of acemetacin | Troponwerke GmbH & Co. KG (DE) | 1984-12-05 | — | — | EP | claimed |
| EP-0114886-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE. | SUNSHINE ABRAHAM (US) | 1984-08-08 | — | — | EP | claimed |
| WO-1984000490-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1984-02-16 | — | — | WO | claimed |
| EP-0087655-A1 | Process for the preparation of acemetacin | Troponwerke GmbH & Co. KG (DE) | 1983-09-07 | — | — | EP | claimed |
| US-4332727-A | BY CYCLIZING THE CORRESPONDING HYDRAZONE | TROPONWERKE GMBH & CO. KG (DE) | 1982-06-01 | — | — | US | claimed |
| US-4309420-A | Stable injectable solutions of indoleacetic acid derivatives | A. NATTERMANN & CIE. GMBH (DE) | 1982-01-05 | — | — | US | claimed |