Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15643677 | 0.84 | MAPT (0.40) | MAPTNPC1MAPK1L3MBTL1MEN1 | |
| SCHEMBL723151 | 0.84 | MAPT (0.40) | MAPTNPC1MAPK1L3MBTL1MEN1 | |
| SCHEMBL29763577 | 0.78 | MAPT (0.42) | KCNN4MAPTMAPK1L3MBTL1MEN1 | |
| SCHEMBL4287836 | 0.72 | GABRA1 (0.37) | MAPTNPC1GAAKMT2ARAB9A | |
| SCHEMBL7191113 | 0.72 | TSHR (0.50) | MAPTGAAKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL19026475 | 0.70 | MAPT (0.36) | KCNN4MAPTKMT2ALMNATDP1 | |
| SCHEMBL10518608 | 0.70 | POLB (0.41) | KCNN4MAPTNPC1GAAL3MBTL1 | |
| SCHEMBL1788771 | 0.70 | KCNN4 (0.43) | KCNN4MAPTGAAKCNE1KCNQ1 | |
| SCHEMBL7185639 | 0.69 | ALDH1A1 (0.43) | MAPTKDM4EKMT2ASMN1; SMN2LMNA | |
| SCHEMBL28990619 | 0.69 | KCNN4 (0.44) | KCNN4KCNE1KCNQ1PARP10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598170-A2 | DRUG-LIGAND CONJUGATES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO | Smartcells, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012015681-A2 | DRUG-LIGAND CONJUGATES, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO | SMARTCELLS, INC. (US) | 2012-02-02 | — | — | WO | disclosed |