Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18875231 | 0.86 | MAPT (0.63) | MAPTKDM4EMEN1KMT2ATSHR | |
| SCHEMBL11869096 | 0.85 | KDM4E (0.55) | MAPTKDM4EMEN1KMT2ATSHR | |
| SCHEMBL7573646 | 0.84 | NPC1 (0.56) | MAPTKDM4EMEN1KMT2ATSHR | |
| SCHEMBL12861182 | 0.84 | PTGS2 (0.60) | MAPTKDM4EMEN1KMT2ATSHR | |
| SCHEMBL17880694 | 0.83 | KDM6B (0.61) | MAPTKDM4EMEN1KMT2ATSHR | |
| SCHEMBL7578683 | 0.82 | ESR1 (0.52) | MAPTKDM4EMEN1KMT2AESR1 | |
| SCHEMBL10415479 | 0.81 | MAPT (0.62) | MAPTKDM4EMEN1KMT2ATSHR | |
| SCHEMBL11381588 | 0.81 | PTGS2 (0.49) | MAPTKDM4EMEN1KMT2ATSHR | |
| SCHEMBL10385204 | 0.81 | MAPT (0.53) | MAPTKDM4ETSHRESR1ESR2 | |
| SCHEMBL16459759 | 0.80 | NPC1 (0.67) | MAPTKDM4EMEN1KMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007039146-A1 | 4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007039146-A1 | 4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-12 | — | — | WO | disclosed |