Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | CASR | P41180 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5307935 | 0.94 | TP53 (0.44) | POLBRXFP1MAPTP2RX7GNRHR | |
| SCHEMBL5312354 | 0.93 | TP53 (0.42) | POLBRXFP1MAPTP2RX7GNRHR | |
| SCHEMBL5307893 | 0.91 | THRB (0.41) | POLBRXFP1MAPTP2RX7GNRHR | |
| SCHEMBL14542013 | 0.91 | MAPT (0.40) | POLBRXFP1MAPTP2RX7GNRHR | |
| SCHEMBL5311965 | 0.90 | GNRHR (0.39) | POLBRXFP1P2RX7GNRHRROCK2 | |
| SCHEMBL5308608 | 0.88 | CHRM1 (0.41) | P2RX7GNRHRCASRKDM4ESMN1; SMN2 | |
| SCHEMBL5310323 | 0.87 | CASR (0.52) | POLBRXFP1MAPTCASRSMN1; SMN2 | |
| SCHEMBL5309516 | 0.87 | CASR (0.40) | MAPTGNRHRROCK2CASRKDM4E | |
| SCHEMBL14542101 | 0.87 | GNRHR (0.39) | POLBGNRHRROCK2CASRKDM4E | |
| SCHEMBL5308637 | 0.87 | P2RX7 (0.42) | MAPTP2RX7GNRHRCASRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |