Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 3/20 | 0.40 |
| ▸ | CASR | P41180 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14542101 | 0.91 | GNRHR (0.39) | CHRM1MEN1KMT2AGNRHRCASR | |
| SCHEMBL5308637 | 0.91 | P2RX7 (0.42) | MEN1KMT2AGNRHRCASRKDM4E | |
| SCHEMBL5307935 | 0.91 | TP53 (0.44) | MEN1KMT2AGNRHRCASRKDM4E | |
| SCHEMBL5312354 | 0.88 | TP53 (0.42) | CHRM1MEN1KMT2AGNRHRCASR | |
| SCHEMBL5308342 | 0.88 | POLB (0.48) | CHRM1MEN1KMT2AGNRHRCASR | |
| SCHEMBL5310639 | 0.88 | CASR (0.48) | MEN1KMT2AGNRHRCASRCYP1A2 | |
| SCHEMBL5310145 | 0.87 | CASR (0.51) | CHRM1CASRKDM4EALDH1A1HPGD | |
| SCHEMBL5311950 | 0.87 | GNRHR (0.37) | CHRM1MEN1KMT2AGNRHRCASR | |
| SCHEMBL5307893 | 0.87 | THRB (0.41) | MEN1KMT2AGNRHRCASRKDM4E | |
| SCHEMBL14542013 | 0.87 | MAPT (0.40) | MEN1KMT2AGNRHRCASRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |